相关实验视频

Updated: Sep 10, 2025

Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling
09:51

Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling

Published on: July 26, 2017

12.5K

TLR4al感知heme作为关键的损伤/危险相关分子模式,以激活下层脊椎动物的免疫反应

Ningxia Xiong1,2, Maolin Lv1, Jingjing Zhang1

  • 1Hubei Hongshan Laboratory, College of Fisheries, Huazhong Agricultural University, Wuhan, China.

Journal of immunology (Baltimore, Md. : 1950)
|August 19, 2025
PubMed
概括

收费类受体4 (TLR4) 在鱼类中发生了不同的进化,局部化到溶酶体,并识别诸如heme等多种连接体. 这项研究阐明了TLR4在下脊椎动物中的演变和功能,影响了对免疫反应和血溶性疾病的理解.

关键词:
垃圾填埋场是一个垃圾填埋场.这里是Heme Heme.在TLR4al中.连接器识别 连接器识别溶酶体局部化发生.

更多相关视频

Using RNA-interference to Investigate the Innate Immune Response in Mouse Macrophages12:47

Using RNA-interference to Investigate the Innate Immune Response in Mouse Macrophages

Published on: November 3, 2014

11.7K
Automated Separation of C. elegans Variably Colonized by a Bacterial Pathogen11:18

Automated Separation of C. elegans Variably Colonized by a Bacterial Pathogen

Published on: March 21, 2014

8.5K

相关概念视频

Transduction01:16

Transduction

Among the three main modes of HGT—transformation, conjugation, and transduction—transduction is unique in that it is mediated by bacteriophages, or bacterial viruses.Transduction occurs in two ways. Generalized transduction occurs during the lytic cycle of a bacteriophage infection. In this process, bacteriophages infect bacterial cells, replicate within them, and ultimately cause cell lysis, releasing newly assembled virions. Occasionally, random fragments of the bacterial genome...
98
NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
7.8K
Formation of Lipopolysaccharides01:19

Formation of Lipopolysaccharides

Lipopolysaccharides (LPS) are crucial components of the outer membrane of Gram-negative bacteria, serving both structural and functional roles. It contributes to membrane stability and protects bacteria from host immune responses. LPS is composed of three major regions—lipid A, a core oligosaccharide, and an O antigen. The biosynthesis and assembly of LPS involve a highly coordinated set of enzymatic reactions and transport mechanisms. Additionally, LPS is recognized as an endotoxin,...
98
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.5K