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Updated: Sep 10, 2025

Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation
15:05

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Published on: May 20, 2020

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作为EGFR抑制剂的贝蒂基衍生物的设计和合成

Xiaotian Xu1, Huan He1, Qian Guo1

  • 1NMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening & Guangdong-Hongkong-Macao Joint Laboratory for New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.

Bioorganic chemistry
|August 19, 2025
PubMed
概括

新的贝蒂基衍生物显示出作为非小细胞肺癌中表皮生长因子受体 (EGFR) 新型全抑制剂的前景. 化合物2b有效地抑制癌细胞的增殖并诱导细胞亡,为抗药性提供了潜在的新策略.

关键词:
这是C797S突变.欧洲农业基金会 (EGFR) 是一个.在L858R/T790M突变中.在NSCLCLC中,我们可以看到NSCLCLC.

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