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Updated: Sep 10, 2025

Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling
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Published on: July 26, 2017

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基于结构的合理设计的TLR7/8对抗剂通过对抗剂脚手架再工程为牛皮治疗治疗

Peixi Wu1, Qiuyue Fu1, Siwei Zhou1

  • 1Guangdong Provincial Key Laboratory of New Drug Screening, NMPA Key Laboratory for Research and Evaluation of Drug Metabolism and Guangdong-Hong Kong-Macao Joint Laboratory for New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China.

European journal of medicinal chemistry
|August 19, 2025
PubMed
概括

研究人员开发了包括SMU-R39在内的新型Toll-like受体7和8 (TLR7/8) 抗剂,用于治疗牛皮等自身免疫性疾病. 这些化合物有效地抑制TLR7/8,在临床前模型中减少炎症和皮肤损伤.

关键词:
抗炎药物 抗炎药物 抗炎药物牛皮病是什么意思 牛皮病作为TLR7/8的对手.

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