在接受辅助生殖技术的妇女中,环境温度,热量暴露和卵巢储量减少
Xinyu Ji1, Baode Xue1, Ningxin Zhang1
1Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Ecotoxicology and environmental safety
|August 19, 2025
概括
暴露于更高的温度和热浪会增加接受生育治疗的女性卵巢储量减少 (DOR) 的风险. 这项研究强调了短期温度变化和长期热浪对生殖健康的影响.
科学领域:
- 环境健康 环境健康
- 生殖内分泌学 生殖内分泌学
- 不孕症研究 不孕症研究
背景情况:
- 卵巢储备减少 (DOR) 影响了接受辅助生殖技术 (ART) 的女性的生育能力.
- 环境热暴露对DOR的影响尚不清楚.
- 了解环境风险因素对于ART结果至关重要.
研究的目的:
- 在接受ART的妇女中调查环境热暴露和DOR之间的关联.
- 分析短期和长期的热暴露窗口和热浪事件.
- 确定与DOR风险增加相关的特定温度值和持续时间.
主要方法:
- 在中国武汉接受ART治疗的4296名妇女的回顾性队列研究.
- 根据住宅地址估计的环境温度和热浪暴露.
- 用于评估DOR (AMH <1.1 ng/mL) 的几率比率的多变量逻辑回归.
主要成果:
- 一个月内平均,最大和表面温度的增加与DOR.的更高几率有关.
- 一年暴露于热浪 (≥35°C,>3天) 显示DOR的几率增加了64%.
- 低频热浪超过1-3年和低持续时间热浪超过3年与DOR风险增加有关.
结论:
- 较高的环境温度和热浪暴露与卵巢储备减少的风险增加有关.
- 短期的温度变化和长期的低频热浪都会导致DOR风险.
- 研究结果强调需要在生殖健康研究和临床实践中考虑各种热暴露模式.
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