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在MOG抗体阳性视神经炎中视觉功能障碍的结构和功能生物标志物:一个范围审查

Fiona Chan¹, Clare Fraser², Fabienne Brilot³

¹Translational Neuroimmunology Group, Kids Neuroscience Centre and ANZAC Research Institute, Sydney Medical School, Faculty of Medicine and Health, University of Sydney, Sydney, Australia; Department of Neurology, Concord Clinical School, Concord Hospital, Sydney, Australia.

Journal of neuroimmunology

|August 19, 2025

概括

线性神经炎 (ON) 可能导致显著的视力损失,但标准敏度测试可能会忽略微妙的缺陷. 多模式评估对于准确的评估和改善患者治疗结果至关重要.

科学领域:

眼科医生眼科眼科
神经免疫学神经免疫学
神经学神经学

背景情况:

髓-寡腺细胞糖蛋白抗体相关疾病 (MOGAD) 经常呈现为视神经炎 (ON).
在MOG-IgG ON中,视觉功能障碍需要超越标准视觉敏度的全面评估.
眼科结构生物标志物和辅助结果测量是理解MOGAD ON.的关键.

研究的目的:

在MOG-IgG ON.中审查视觉功能障碍的文献.
专注于眼科结构生物标志物和辅助结果措施.
为了确定MOG-IgG ON.目前的评估方法中的差距.

主要方法:

使用以下术语进行系统的PubMed搜索 (2007-2025年): "视觉神经炎"",视觉结果"",髓-氧基细胞糖蛋白".
评估高对比度视敏度 (HCVA),低对比度视敏度 (LCVA),对比度灵敏度,视野 (VF),电生理学,光学连贯性断层扫描 (OCT) /血管学,磁共振成像 (MRI) 和生活质量 (QoL).

主要成果:

分析了35项研究和2335名患者;89%的人报告HCVA,63%的OCT,43%的MRI.
MOG-IgG ON显示了中度至重度的HCVA损失在最低点,恢复良好,但OCT显示了轴突损失,尽管保留了HCVA.
辅助测试 (VF,LCVA,VEPs) 即使在正常的HCVA中也显示出异常,表明结构功能不一致.

结论:

目前的临床评估可能低估了MOG-IgG ON中的视觉功能障碍.
未来的,纵向的多式联络评估对于识别敏感生物标志物至关重要.
将敏感生物标志物纳入临床实践可以改善患者的管理和生活质量.

关键词:

骨髓-小基细胞糖蛋白抗体.视神经炎是一种视神经炎.光学连贯性断层扫描仪预测预后预测预测治疗方法治疗方法视力受损视力受损视力受损

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