益生菌在患有Blastocystis spp.的患者中具有抗炎作用. 感染的感染感染
Magda S A Abdeltawab1, Shimaa M Abdel Aal1, Shaimaa Mohammed Ali2
1Department of Medical Parasitology, Faculty of Medicine, Cairo University, Cairo, Egypt.
Cytokine
|August 19, 2025
概括
益生菌疗法有效地减少了Blastocystis hominis感染的肠道炎症,降低了便中的calprotectin和TNF-α水平. 它与甲尼达产生了协同作用,改善了浮气和腹痛等症状.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
背景情况:
- 胚胎细胞原体 (BH) 感染与肠道免疫病理有关.
- 益生菌疗法可以通过调节免疫反应来减轻胚囊炎的胃肠道炎症.
研究的目的:
- 评估益生菌疗法,美特罗尼达及其组合在治疗Blastocystis hominis感染中的疗效.
- 评估对胃肠道症状的影响,便calprotectin (FCP) 和瘤缩因子α (TNF-α) 的水平.
主要方法:
- 一百名BH感染患者被随机分为四组:没有治疗,益生菌治疗,甲尼达或联合治疗.
- 治疗包括7天的Lacteol forte (Lactobacillus acidophilus LB) 或10天的metronidazole (250毫克每天三次).
- 测量了临床症状,FCP和TNF-α水平,以评估治疗结果和炎症.
主要成果:
- 益生菌治疗显著降低了腹部疼痛,并且与单独使用美트로尼达相比,显示出改善胀的趋势.
- 便中calprotectin (FCP) 水平在益生菌组中最低,这表明肠道炎症减少.
- 在所有治疗组中,瘤亡因子α (TNF-α) 水平显著下降,益生菌治疗显示出显著的减少.
结论:
- 益生菌疗法,特别是与乳酸细菌酸性 (Lactobacillus acidophilus LB) 进行的疗法,有效缓解与Blastocystis hominis感染相关的肠道炎症.
- 益生菌在与美特罗尼达结合时显示出潜在的协同效应,提供更好的症状管理和减少炎症标志物.
- 益生菌干预代表了一种有前途的治疗策略,用于管理与芽细胞瘤相关的胃肠道问题.
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