干眼病和糖尿病之间是否存在联系? 一个系统的审查和元分析
Kai-Yang Chen1, Hoi-Chun Chan2, Chi-Ming Chan3
1Department of General Medicine, Chang Gung Memorial Hospital (Linkou branch), Taoyuan, Taiwan.
Journal of diabetes and its complications
|August 19, 2025
概括
糖尿病患者的干眼病 (DED) 患病率明显更高. 诸如年龄较大,糖尿病持续时间较长和血糖控制不佳等因素会增加糖尿病患者的DED风险.
科学领域:
- 眼科医生 眼科 眼科
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 皮质结膜炎 sicca (干眼病,DED) 是一种常见的眼睛表面疾病.
- 越来越多的兴趣将DED与糖尿病 (DM) 联系起来.
研究的目的:
- 系统地审查和对现有文献进行元分析.
- 评估DM和DED之间的关联.
- 为了确定糖尿病患者中DED发展的风险.
主要方法:
- 搜索了四个数据库 (PubMed,Cochrane,Web of Science,Google Scholar) 的英语,同行评审的文章.
- 包括过去10年发表的关于糖尿病人群中DED患病率的报告研究.
- 使用随机效应模型与几率比率 (OR) 和风险比率 (RR) 进行统计分析.
主要成果:
- 包括23项研究,5566名参与者.
- 糖尿病患者的DED患病率显著增加 (OR: 2.30,RR: 1.69).
- 与年龄较大,糖尿病持续时间较长,血糖控制较差 (HbA1c>7%) 相关的DED风险增加.
- 机制包括氧化应激,炎症和神经病变.
结论:
- 证实了DM和DED患病率/严重程度之间的显著关联.
- 糖尿病患者面临更高的DED风险,特别是患有2型糖尿病的老年人.
- 优先考虑在糖尿病人群中早期发现和管理DED,以改善生活质量.
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