石榴 (Punica granatum L.):对其对毒性保护作用的叙述性审查
Zahra Yazdanpanah1, Ali Sirjani2, Elnaz Vafadar Moradi3
1Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Fitoterapia
|August 19, 2025
概括
石榴通过减少损伤,炎症和氧化应激,表现出显著的脏保护作用. 它的生物活性化合物有助于促进脏健康和减轻毒性.
科学领域:
- 药理学和毒理学 药理学和毒理学
- 自然产品化学 自然产品化学
- 脏生理学 脏生理学
背景情况:
- 石榴 (Punica granatum L.) 传统上以其健康益处而闻名,特别是在支持功能方面.
- 它富含多和黄的丰富特征表明,它可能有针对毒性的保护作用.
研究的目的:
- 审查石榴及其成分在预防脏损伤和增强脏健康方面的疗效.
- 阐明石榴的脏保护作用背后的机制.
主要方法:
- 从2010年到2025年进行了全面的文献审查.
- 研究来源来自主要的科学数据库 (Scopus,谷歌学者,科学网,PubMed).
- 专注于体外和体内研究,研究石榴对毒性的影响.
主要成果:
- 石榴的脏保护与生物活性化合物,如酸,酸和punicalagin有关,这些化合物具有抗氧化和抗炎性质.
- 这些化合物调节关键信号通路 (例如TGF-β1 / Smad,SIRT1,Nrf2) 并减少损伤标志物 (例如MCP-1,NF-κB,KIM-1).
- 石榴保持了膜过率,减少了管状损伤,并支持脏修复机制.
结论:
- 石榴通过调节氧化应激,炎症,纤维化和亡,表现出多方面的脏保护作用.
- 需要进一步的临床研究来验证发现,探索应用,并评估安全性.
- 石榴的活性成分在管理脏健康和打击毒性方面表现有前途.
相关概念视频
01:14Prevention of Further Absorption of Poison
925
In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
925
01:26Enhanced Elimination of Poison
577
Poison can be effectively removed from the gastrointestinal (GI) tract through various decontamination procedures.
Antidotes serve a crucial role in counteracting the effects of poison by inhibiting enzymes responsible for producing harmful drug metabolites. In some cases, these toxic metabolites can be neutralized by endogenous cosubstrates, which are maintained at specific concentrations to prevent interaction with cellular macromolecules and subsequent cell death.
Renal excretion is the...
Antidotes serve a crucial role in counteracting the effects of poison by inhibiting enzymes responsible for producing harmful drug metabolites. In some cases, these toxic metabolites can be neutralized by endogenous cosubstrates, which are maintained at specific concentrations to prevent interaction with cellular macromolecules and subsequent cell death.
Renal excretion is the...
577
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
57
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
57
01:27Urinary Tract Calculi IV: Nutrition Therapy and Prevention
31
Management of renal calculi focuses on effective strategies like tailored nutrition and hydration therapy. Adjusting diet and fluid intake reduces stone formation and recurrence, making these interventions simple yet powerful in kidney stone prevention and management.Understanding Kidney StonesKidney stones form when calcium, oxalate, uric acid, and cystine concentrate and crystallize in urine. Factors contributing to their formation include genetic predisposition, certain medical conditions,...
31
01:11Renal Failure: Dose Adjustments
153
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
153
01:15Renal Drug Excretion: Overview
269
As primary excretory organs, the kidneys maintain homeostasis by removing waste substances from the bloodstream. They comprise over a million units called nephrons, which serve as the kidney's functional units.
A nephron consists of two primary structures: the renal corpuscle and the renal tubule. The renal corpuscle contains the glomerulus, a network of capillaries where the first step of renal excretion, glomerular filtration, occurs. Blood pressure forces water, ions, and small molecules...
A nephron consists of two primary structures: the renal corpuscle and the renal tubule. The renal corpuscle contains the glomerulus, a network of capillaries where the first step of renal excretion, glomerular filtration, occurs. Blood pressure forces water, ions, and small molecules...
269