长期营养状况在患有食道的儿童出生
Madeleine Aumar1,2, Suzanne Depoortere2, Matthieu Antoine2
1University of Lille, Inserm, Centre Hospitalier Universitaire Lille, U1286, Institute for Translational Research in Inflammation, Lille, France.
Pediatrics
|August 19, 2025
概括
患有食道缩症 (EA) 的儿童面临营养不良和衰老的长期风险. 早期干预和密集的营养后续对高风险患者至关重要.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 营养科学 营养科学
- 遗传性缺陷 遗传性缺陷是一种先天性缺陷
背景情况:
- 食道缩症 (EA) 与早期营养不良和受影响儿童的生长延迟有关.
- 在EA患者的长度营养状况需要进一步调查.
研究的目的:
- 评估患有食道缩症 (EA) 出生的儿童的长期营养状况.
- 确定EA患者年龄在16岁以下的营养不良和衰老相关的风险因素.
主要方法:
- 一项从出生到16岁的204名患有EA的儿童 (91%患有气管食道) 的纵向研究.
- 营养不良 (BMI Z-score < -2 SD) 和衰老 (HFA Z-score < -2 SD) 的评估.
- 使用回归模型对间隔审查数据进行风险因素分析.
主要成果:
- 与正常人群相比,患有EA的儿童在16岁之前的平均BMI和身高相对年龄的Z-分数始终较低.
- 在12岁时,BMI Z-score接近正常范围,但身高对年龄的Z-score仍然显著不同.
- 一年后,累计衰竭的发病率为7%,其中25%的人在1至16岁之间至少经历过一次营养不良.
- 营养不良的重要风险因素包括先天性心脏形,产前EA诊断和质子抑制剂 (PPI) 使用.
- 发育迟缓的重要风险因素包括遗传异常,多胎妊娠,胃口切除术和1岁后使用PPI.
结论:
- 患有EA的儿童在整个童年和青春期仍然存在营养不良和发育迟缓的高风险.
- 尽管医学进步,积极的营养监测和早期干预对于高风险的EA人群至关重要.
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