齐普罗对术后痴呆症的影响以及接受重大胸部手术的老年患者的结果:多中心,前性,单盲,随机对照研究的协议
Pu Hong1,2, Qian Liu1, Wen Ouyang3
1Department of Anesthesiology, Xuanwu Hospital Capital Medical University, Beijing, Beijing, China.
这项研究调查了新型镇静剂西普罗是否可以减少胸部手术后老年人患上术后妄想症 (POD),与普罗普罗相比. 调查结果将澄清西普罗的含量.
科学领域:
- 麻醉学和老年人手术
背景情况:
- 手术后痴呆症 (POD) 在接受重大胸部手术的老年患者中是一个重大问题.
- 新型镇静剂西普罗对血液动力学稳定性和潜在的减少POD有希望,但证据有限.
研究的目的:
- 为了比较西普罗与普罗波在降低胸部手术的老年患者中POD发病率方面的疗效.
- 评估西普罗对各种术后结果的影响.
主要方法:
- 这是一项多中心,前性,单盲,随机对照试验,涉及65岁以上接受选择性胸腔镜手术的患者.
- 随机分配给西普罗或普罗波,使用3D-CAM作为主要结果评估POD发病率.
- 样本大小为214名参与者,POD发病率的非劣势率为5%.
主要成果:
- 主要结局:手术后7天内POD发生率.
- 二次结局:出现妄想,不良事件,低血压,停留时间,以及第一次口服的时间.
- 计划进行非劣势分析,以比较西普罗和普罗波.
结论:
- 这项研究旨在提供高质量的证据,证明普罗在胸部手术后预防POD中的作用.
- 结果将为临床实践提供有关老年手术患者选择镇静剂的信息.
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