患有左侧与右侧乳腺癌的女性心血管事件的发生率:一种倾向性得分匹配的研究
Laurent Fauchier1, Lisa Lochon2, Thibault Lenormand2
1Université François Rabelais Tours, Tours, France lfau@med.univ-tours.fr.
Heart (British Cardiac Society)
|August 19, 2025
概括
与右侧BC相比,左侧乳腺癌 (BC) 与心房的风险略高. 这项研究没有发现基于BC横向性的整体死亡或其他心血管事件的显著差异.
科学领域:
- 心脏病学 心脏病学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 乳腺癌 (BC) 疗法可能导致心脏毒性,增加心血管疾病,特别是心房动 (AF).
- 对心血管事件发生率的BC横向性的影响尚不清楚.
- 这项研究调查了左侧与右侧BC的侧面性特异性心血管风险.
研究的目的:
- 评估乳腺癌患者与横向性相关的心血管风险.
- 为了比较左侧和右侧乳腺癌之间的心房动和其他心血管事件的发生率.
- 分析放射治疗对横向特异性心血管风险的影响.
主要方法:
- 利用来自TriNetX网络的全球医疗保健数据进行大型国际队列研究.
- 雇员倾向得分匹配 (1:1) 创建可比的左侧或右侧BC的女性队列.
- 随访患者长达8年,评估死亡率,AF,心室动脉节律失常,心力衰竭和ICD植入.
主要成果:
- 与右侧BC相比,左侧BC显示出一个统计学上显著的,尽管从数值上是边际的,较高的心房动 (AF) 风险 (HR 1.051).
- 两组之间在所有死因或整体发生心血管事件中没有发现显著差异.
- 与左侧BC相关的AF风险增加与放射治疗状态没有显著的相互作用.
结论:
- 与右侧乳腺癌相比,左侧乳腺癌与心房的风险明显高.
- 乳腺癌的横向性似乎没有影响所有死因或其他主要心血管事件的风险.
- 这些发现强调了在心血管风险评估中考虑乳腺癌横向性的重要性.
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