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在冠状动脉疾病的老年人中,多变量白质微观结构的改变

Stefanie A Tremblay^1,2,3, Zacharie Potvin-Jutras^1,2,3, Dalia Sabra^1,2,4

¹Physics Department, Concordia University, 7141 Rue Sherbrooke W, Montréal, QC, H4B 1R6, Canada.

The Journal of neuroscience : the official journal of the Society for Neuroscience

|August 19, 2025

概括

冠状动脉疾病 (CAD) 与白质 (WM) 微观结构变化有关,特别是影响髓. 这些大脑变化与较慢的处理速度相关,增加认知障碍的风险.

科学领域:

神经成像是一种神经成像.
心血管疾病研究研究
认知神经科学认知神经科学

背景情况:

冠状动脉疾病 (CAD) 患者表现出认知障碍,痴呆和中风的风险增加.
白质病变 (WM) 在CAD中很常见,但微观结构变化尚未得到充分理解.
了解CAD中的WM变化对于预测认知衰退至关重要.

研究的目的:

在CAD患者与健康对照者 (HC) 中识别WM微观结构变化.
研究WM变化与认知表现 (执行功能,处理速度) 之间的关系.
确定导致CAD中WM异常的关键MRI指标.

主要方法:

招募了43名CAD患者和36名HC (50岁以上).
使用了综合的神经心理测试和多模式3TMRI (扩散权重成像,R1放松计,磁化转移成像).
应用了一种新的多变量Mahalanobis距离 (D2) 方法来量化WM异常,整合多个指标.

主要成果:

与HC相比,CAD患者在整个WM和特定动脉区域中显示出显著更高的D2值.
对髓敏感的指标 (R1放松率,MT和) 是D2差异的主要驱动因素.
较慢的处理速度与WM和左中脑动脉区域中较高的R1有关.

结论:

CAD与广泛的WM微观结构变化有关,主要是由髓变化驱动的.
这些与髓相关的WM变化可能是CAD患者认知障碍风险增加的基础.
研究结果强调了心血管健康,大脑结构和认知功能之间的联系.

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