配对的关联性电和经磁刺激诱导了人体初级运动皮层中的可塑性
Meiqi Lai1, Jiaxin Xiao2, Jie Zhan1
1Acupuncture Research Team, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, China.
电配对关联刺激 (EA-PAS) 调节原发动皮质 (M1) 刺激能力,特定的时间 (刺激间隔) 确定增加或减少. 这种非侵入性技术显示出神经恢复的前景.
科学领域:
- 神经科学是一个神经科学.
- 康复医学 康复医学 康复医学
- 神经调节是一种神经调节.
背景情况:
- 配对关联性刺激 (PAS) 通过使用跨磁刺激 (TMS) 和外围神经刺激,非侵入性调节原发动性皮质 (M1) 刺激能力.
- 电针 (EA) 和TMS对M1兴奋性的联合影响尚不清楚.
研究的目的:
- 研究一种新型EA-PAS协议,将EA和TMS集成到M1上,对M1兴奋性的影响.
- 为了确定EA-PAS是否会引起与传统PAS类似的调制效应.
主要方法:
- 20名健康受试者参与了这项研究.
- 在基线和干预后的七个时间点记录了发动机唤起的潜能 (MEP) 幅度.
- 应用了不同的EA-PAS协议,具有不同的刺激间间隔 (ISI).
主要成果:
- 具有 17,25 和 35 ms 的 ISI 的 EA-PAS 协议增加了 M1 的兴奋性.
- 具有10和14毫秒的ISI的EA-PAS协议降低了M1的兴奋性.
- 单独EA和TMS都没有产生显著的变化;影响是EA-PAS和目标肌肉的特征.
结论:
- 根据ISI,EA-PAS有效调节人类M1刺激能力.
- 确定了调节M1兴奋性的新时间窗口.
- 在神经康复中,EA-PAS显示了未来应用的潜力.
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