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Updated: Sep 10, 2025

Yeast As a Chassis for Developing Functional Assays to Study Human P53
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Published on: August 4, 2019

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胚胎内 TP53 变种损害了 p53 寡合化,使人易患癌症

Lucie Vanikova1, Eva Machackova2, Barbora Nemcova3

  • 1Cancer Cell Biology, Institute of Molecular Genetics of the Czech Academy of Sciences, 14220, Prague, Czech Republic.

Scientific reports
|August 19, 2025
PubMed
概括

一种新的TP53基因变异,p.E339_F341del,通过损害瘤抑制活性,导致Li-Fraumeni综合征 (LFS). 这一发现促进了对LFS和潜在治疗点的理解.

关键词:
癌症 癌症 癌症 癌症李·弗劳梅尼综合征 李·弗劳梅尼综合征这就是TP53的特点.在p53中,p53是什么?

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