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加速度计测量身体活动和抑郁症之间的剂量反应关系:来自英国生物银行的证据

Shuangfa Qu^1,2, Zhenhua Xing^3,4

¹Department of Emergency Medicine, Second Xiangya Hospital, Central South University, Changsha, 410011, China.

Translational psychiatry

|August 19, 2025

概括

身体活动,包括轻度,中度和强度,可以降低抑郁症的风险. 然而,益处平稳,轻度活动对女性或肥胖个体没有任何保护. 对这些群体来说,仍然建议进行中度至强度的活动.

科学领域:

流行病学流行病学
公共卫生公共卫生
运动科学运动科学

背景情况:

大多数关于体力活动 (PA) 和抑郁症的研究都使用自我报告,重点关注中度至强烈的PA (MVPA).
有限的研究存在于加速仪测量PA,特别是轻度体力活动 (LPA) 和一般人群的抑郁风险.

研究的目的:

为了研究加速仪测量PA和抑郁风险之间的剂量反应关系.
为了检查不同PA强度 (LPA,MPA,VPA) 和总PA体积对抑郁症的影响.
探索PA对抑郁症的影响是否在女性和肥胖患者等高风险群体中不同.

主要方法:

来自英国生物银行 (UK Biobank) 的90,585名参与者的前性队列研究,使用加速度计数据.
评估的PA总体体积 (平均总加速) 和LPA,MPA和VPA的每周分钟.
使用具有受限立方线的Cox比例危险模型来分析平均8.35年随访期间的抑郁症发病率.

主要成果:

抑郁症的风险随着LPA,MPA和VPA的总PA量和时间增加而降低,达到一定值 (每周30毫克ACC,2000分钟LPA,500分钟MPA,50分钟VPA).
较高强度的PA (VPA) 与总PA量相似时的较低强度相比没有提供额外的抑郁风险降低.
与一般人群不同的是,LPA的保护作用在女性和肥胖个体中并不显著.

结论:

所有强度的加速器测量PA与抑郁症风险降低有关,主要是由体积而不是强度驱动的.
存在一个值效应,超出这个值效应后,增加的PA收益率导致抑郁风险降低的收益率下降.
虽然整体PA是有益的,但MVPA仍然是女性和肥胖个人的推强度,以减轻抑郁风险.

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