埃及人口中的全身性硬化症,重点是临床和指甲毛细血管学特征
Amira Elsonbaty1, Manal Hassanien2, Abdelhfeez Moshrif3
1Rheumatology & Rehabilitation and Physical Medicine Department, Faculty of Medicine, Assiut University, Assuit, Egypt. Dramiramelsonbaty@gmail.com.
Scientific reports
|August 19, 2025
概括
患有全身性硬化症 (SSc) 的埃及患者表现为严重的疾病,预后不佳. 爪毛细膜镜 (NFC) 显示了与疾病严重程度和器官参与的关联,这表明早期使用可能会改善结果.
科学领域:
- 类风湿病学 类风湿病学
- 皮肤病学 皮肤病学
- 内部医学 内部医学
背景情况:
- 系统性硬化症 (SSc) 是一种复杂的自身免疫性疾病,其特点是纤维化,血管病变和免疫失调.
- 了解埃及人等不同人口中的特定的人口,临床和毛细管学特征对于量身定制的管理至关重要.
- 之前的研究已经强调了全球SSc呈现和进展的差异.
研究的目的:
- 描述埃及SSc.患者的人口统计学,临床,实验室和指甲折毛细膜学 (NFC) 的特征.
- 调查NFC发现与内部器官参与,疾病严重程度和其他临床参数之间的相关性.
- 将埃及SSc患者的疾病特征和预后与国际队列进行比较.
主要方法:
- 一个横截面的,多中心的前性分析,涉及222名被诊断患有SSc的埃及成年患者.
- 收集有关人口统计,临床表现 (包括修改的罗丹皮肤评分 - MRSS),内脏器官参与,成像和实验室测试的数据.
- 在144名患者身上进行了指甲折叠毛细管透视 (NFC),以评估微血管变化.
主要成果:
- 该队列主要由中年女性 (91%) 组成,SSc (62.6%) 有限.
- 观察到高患病率的周围血管,肺 (56.8%与肺高血压),和胃肠道的表现,往往与严重的疾病概况.
- NFC模式与自身抗体,疾病严重程度和特定器官参与 (一般,肠道,肌病,数字) 有显著的相关性,但不是SSc类型.
结论:
- 与全球平均水平相比,埃及SSc患者呈现严重疾病表型和不良预后指标.
- 爪毛细膜镜显示了与各种疾病方面的重要关联,特别是在活跃和晚期阶段.
- 早期整合NFC可能会增强疾病管理,并可能改善系统性硬化症患者的治疗结果.
相关概念视频
Endocarditis II: Clinical Features of Infective Endocarditis
25
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
25
Chronic Kidney Disease II: Clinical Manifestations
87
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
87
Cardiovascular System Abnormal Findings I: Inspection and Palpation
515
In a cardiovascular examination, inspection and palpation are crucial for identifying abnormalities.
Abnormal findings observed during an inspection
Abnormal findings observed during an inspection
515
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
34
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
34
Assessment of the Cardiovascular System II: Inspection
405
Inspection is the initial step in assessing the cardiovascular system. It involves a detailed visual examination that provides crucial information about a patient's circulatory and cardiac health. This systematic process, conducted from head to toe, helps identify signs of cardiovascular conditions by observing physical appearance, skin and mucous membranes, jugular and carotid pulsations, chest symmetry, and the condition of the extremities.
Head and Neck
Head and Neck
405
Nephrotic Syndrome II : Assessment and Medical Management
21
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
21


