由Aggregatibacter segnis引起的皮下:一个罕见病例报告和文献综述
Qinghua Li1, Xiaotong Fan2, Kailiang Wang2
1Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China. 1192728598@qq.com.
BMC infectious diseases
|August 20, 2025
概括
一种罕见的口腔细菌, 在一个免疫能力强的患者中引起皮下. 及时诊断和治疗包括手术和抗生素导致了恢复.
科学领域:
- 神经科学
- 传染性疾病
- 微生物学
背景情况:
- 聚合菌种通常是口腔细菌,在健康个体中很少发生侵入性感染.
- 腹膜下是一种罕见但严重的硬骨母体和骨母体之间的感染.
- 这种病例代表了由Aggregatibacter segnis (A. segnis) 引起的第一个报告的体内.
研究的目的:
- 报告一个罕见的由Aggregatibacter segnis引起的体内.
- 突出诊断挑战和成功管理中枢神经系统罕见感染的策略.
主要方法:
- 一位50岁的女性出现了暗示皮下病变的症状.
- 诊断成像 (CT,MRI) 显示了皮下病变和鼻炎.
- 脑脊液 (CSF) 分析呈病毒或细菌病原体阴性.
- 进行了切除术以疏散,在培养物中发现了A. segnis.
- 除了传统培养方法外,还使用了新一代代基因组测序 (mNGS).
主要成果:
- 聚合菌被确定为皮下的致病原体.
- mNGS和培养结果之间的差异带来了诊断挑战.
- 在手术和抗生素治疗后,患者的临床状况逐渐改善.
结论:
- 在分化诊断时应考虑Aggregatibacter segnis
- 多模式诊断方法对于识别罕见病原体至关重要.
- 及时进行神经外科干预和量身定制的抗菌疗法对于治疗这种感染至关重要.
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