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通过调节肠道微生物群来改善山羊衍生的Lactobacillus amylovorus
Cheng Cheng1,2, Yan Zheng1, Xin Wang1
1College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, 225009, China.
BMC veterinary research
|August 20, 2025
概括
一种来自山羊的新型益生菌Lactobacillus amylovorus有效地恢复了患有小综合征 (FKS) 的山羊的肠道健康. 这种有前途的干预措施改善了肠道微生物群的多样性,减少了有害细菌,为FKS提供了新的治疗方法.
科学领域:
- 兽医微生物学
- 动物益生菌
- 羊的健康
背景情况:
- 由于代谢问题和肠道失调症,症候群 (FKS) 在山羊养殖中造成显著的死亡率.
- 开发有效的干预措施对于减少FKS相关损失至关重要.
研究的目的:
- 为了分离一种来自山羊的益生菌.
- 评估其在受FKS影响的山羊中恢复肠道平衡的有效性.
主要方法:
- 通过16S rRNA测序隔离和确认Lactobacillus amylovorus.
- 对低pH值,胆盐和热量的益生菌耐受性的评估.
- 对大肠杆菌和黄金杆菌等病原体的抗菌活性评估.
- 在FKS受影响的山羊中对肠道微生物群变化的分析.
主要成果:
- 这种L. amylovorus分离物对酸性条件,胆盐和热量有显著的耐受性.
- 它对常见的山羊病原体,大肠杆菌和黄金葡萄球菌有抑制作用.
- 在受FKS影响的山羊中,益生菌治疗导致肠道微生物多样性的显著增加 (香农和辛普森指数).
- 有益品种 (Lactobacillus,Ruminococcus) 的相对丰富度增加,而致病性埃舍里希亚菌 (EscherichiaShigella) 的数量则减少.
结论:
- 来自山羊的L. amylovorus具有强大的益生菌特性,包括病原体抑制和耐受恶劣条件.
- 这种益生菌有效调节了受FKS影响的山羊的肠道微生物群,恢复了稳态.
- L. amylovorus显示出作为一种新型治疗药物的显著潜力,用于预防和治疗软综合征.
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