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Updated: Sep 10, 2025

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells
10:21

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells

Published on: February 21, 2018

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KAT6A仿真体与NURF和MLL/COMPASS形成一个自我强化的表观遗传模块,以维持AML

Junhui Lv1, Zhinang Yin1, Conghui Li1

  • 1State Key Laboratory of Metabolism and Regulation in Complex Organisms, TaiKang Center for Life and Medical Sciences, School of Basic Medical Sciences, Wuhan University, 115 DongHu Road, Research Building III, Room 404, Wuchang District, Wuhan, 430071, China.

Genome biology
|August 20, 2025
PubMed
概括

在急性髓性白血病 (AML) 中,KAT6A融合与预后不佳有关. 这项研究揭示了一种涉及KAT6A,NURF和MLL/COMPASS的新型表观遗传模块,并确定NURF或CBP/P300抑制是AML有前途的治疗策略.

关键词:
洗钱问题急性骨髓性白血病染色体的可访问性其他:其他:其他类型MLL/指南针在 NURF核细胞重塑因子

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