非洲和亚洲的Plasmodium falciparum plasmepsin2/3基因复制的流行情况:系统性审查和元分析
在PubMed上查看摘要
概括
此摘要是机器生成的。基于素的组合疗法 (ACT) 的失败与 Plasmodium falciparum plasmepsin2/3 (pfpm2/ 3) 基因放大有关. 这项元分析发现pfpm2/3放大率总和为16%,亚洲比非洲更高,需要监测以防止疟疾的治疗耐药性.
科学领域
- 疟疾学
- 遗传学
- 公共卫生
背景情况
- 在亚洲和非洲,Plasmodium falciparum的部分抗素导致ACT治疗失败.
- 增强Plasmodium falciparum plasmepsin2/3 (pfpm2/3) 基因降低了对piperaquine的敏感性,导致二甲素治疗失败.
研究的目的
- 系统地审查和总结来自亚洲和非洲的Plasmodium falciparum分离物中的pfpm2/3基因放大证据.
主要方法
- 对来自非洲和亚洲的34项研究进行了系统的分析.
- 数据来源于Medline,Google Scholar,CENTRAL,LILACS和EMBASE,其注册地址为PROSPERO.
- 使用随机效应模型估计了聚合比例,并通过I2统计和按大陆和年份的子组分析来评估异质性.
主要成果
- 在不同研究中观察到很高的异质性 (I2 > 95%).
- 聚合 pfpm2/3 基因放大率为 16. 0% (95% CI 8. 0 - 26. 0%).
- 在亚洲 (25.0%) 和非洲 (8.0%) 的增幅明显高于2016年之前的11%至2016年至2020年 (19%).
结论
- 发生大量pfpm2/3基因放大,特别是在亚洲,对ACT的疗效构成风险.
- 持续监测和控制合作伙伴的耐药性对于防止广泛的ACT耐药性和保护消除疟疾的努力至关重要.
相关概念视频
The seminal work of Ohno in 1970 popularized the idea of gene duplication and divergence. DNA sequence comparison studies reveal that a large portion of the genes in bacteria, archaebacteria, and eukaryotes was generated by gene duplication and divergence, indicating its critical role in evolution.
The duplicated copies of the gene are called Paralogs. Paralogs with similar sequences and functions form a gene family. Across several species, a large number of gene families are...
Alveolates are a group of organisms recognized by the presence of alveoli, which are cytoplasmic sacs located beneath the cell membrane. While their function remains uncertain, alveoli may help regulate water balance by controlling how much water enters and leaves the cell. In dinoflagellates, these structures may serve as armor plates. There are three major types of alveolates: ciliates, which move using cilia; dinoflagellates, which use flagella for movement; and apicomplexans, which are...
Symbiotic relationships are long-term, close interactions between individuals of different species that affect the distribution and abundance of those species. When a relationship is beneficial to both species, this is called mutualism. When the relationship is beneficial to one species but neither beneficial nor harmful to the other species, this is called commensalism. When one organism is harmed to benefit another, the relationship is known as parasitism. These types of relationships often...

