亚托皮炎治疗的进步:从发病到基于天然产品的疗法
Xinyun Fan1, Zibo Liu1, Wenjing Yang1
1School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, People's Republic of China.
Phytotherapy research : PTR
|August 20, 2025
概括
自然产品在治疗亚托皮性皮肤炎 (AD) 中具有前景. 这些化合物可以通过向关键信号通路, 重新平衡免疫细胞并减少炎症, 为这种慢性皮肤疾病提供新的治疗途径.
科学领域:
- 皮肤病学
- 免疫学
- 药理学
背景情况:
- 无形性皮肤炎 (AD) 是一种慢性炎症性皮肤病,影响生活质量和公共健康.
- 阿尔茨海默病的发病包括过敏,炎症,氧化应激和亡的复杂相互作用.
- 目前的治疗挑战促使人们寻找新的治疗点和药物.
研究的目的:
- 审查了解阿尔茨海默病变的最新进展.
- 探索天然产品在阿尔茨海默病治疗中的治疗潜力.
- 确定NP用于AD治疗的关键分子通路.
主要方法:
- 对阿尔茨海默病的发病和NP疗法的最新研究进行文献综述.
- 分析NP机制,包括免疫细胞调节和角质细胞功能.
- 检查NF-κB,MAPK和JAK/STAT等NP调节的信号通路.
主要成果:
- 自然产品 (类,类,类等) 对阿尔茨海默氏症具有治疗潜力.
- 这些NP可以纠正免疫细胞的不平衡,调节质细胞的功能.
- NP调节关键的炎症通路,包括NF-κB,IgE-FcεRI,MAPK和JAK/STAT,以减少巨细胞的激活和细胞因子的分泌.
结论:
- 自然产品为开发新型阿尔茨海默病疗法提供了有前途的策略.
- 用NP准特定的信号通路可以缓解AD症状.
- 需要进一步研究基于NP的化合物设计,药理学和临床试验.
相关概念视频
Asthma: Pathogenesis and Management
581
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
581
Clinical Applications of Epidermal Stem Cells
2.7K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
2.7K
Hypersensitivities
1.0K
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
1.0K
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
453
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
453
Renewal of Skin Epidermal Stem Cells
2.6K
The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
2.6K
Changes in Skin Color: Clinical Perspectives
2.2K
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
2.2K


