静脉注射利多卡因作为老年患者进行同访双向内镜治疗的辅助剂:多中心随机对照试验的方案
在PubMed上查看摘要
概括
此摘要是机器生成的。这项研究旨在研究静脉注射利多卡因是否能在接受双向内镜检查的老年患者中降低治疗过程中的不良反应. 结果旨在优化这一群体的镇静作用.
科学领域
- 麻醉学
- 胃肠病学
- 老年病学
背景情况
- 老年患者经常在镇静下接受双向内镜手术.
- 这种人群的最佳镇静疗法尚不清楚.
- 在接受内镜检查的老年患者中,与镇静相关的不良反应是令人担忧的.
研究的目的
- 评估静脉注射利多卡因是否可以作为辅助剂减少接受双向内镜检查的老年患者的不良反应.
- 测试利多卡因降低手术期间脱和低血压的假设.
主要方法
- 这是一项多中心,随机,双盲,安慰剂对照试验,涉及648名老年患者.
- 患者接受了sufentanil和propofol,以及静脉注射的利多卡因或正常的盐溶液 (安慰剂).
- 主要结论:脱度 (SpO2 < 90%) 和低血压 (SBP < 90 mmHg或降低> 20%) 的组合.
主要成果
- 该研究目前正在招募患者,结果正在等待.
- 主要结局将比较利多卡因和安慰剂组之间的脱和低血压的发生率.
- 二次结局包括普罗波剂量,身体运动,疼痛,疲劳和恢复时间.
结论
- 在接受双向内镜检查的老年患者中,辅助利多卡因可优化息效果.
- 预计这些发现将为这一易受伤害的患者提供镇静策略.
- 这项研究解决了老年人镇静治疗的关键问题.
相关概念视频
Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
Intravenous regional anesthesia or the Bier block technique is used to anesthetize a specific limb or extremity. It uses exsanguinated or blood-drained vessels to transport local anesthetics or LAs to the peripheral nerve trunks. Lidocaine without vasoconstrictors like epinephrine is most commonly used for this technique. Other drugs used are prilocaine, ropivacaine, and chloroprocaine. Bupivacaine is not recommended for this technique due to its high cardiac toxicity.
One of the advantages of...
Local anesthetics (LAs) are commonly used for various applications in medical and dental procedures. Some of the common agents used are cocaine, lidocaine, and bupivacaine.
Cocaine is an ester of benzoic acid and methylecgogine. It is used to anesthetize and vasoconstrict locally. Currently, it is used primarily for topical applications. It is beneficial for surgeries on the upper respiratory tract, providing anesthesia and shrinking the mucosa. Cocaine in the form of cocaine hydrochloride is...
Sigmoidoscopy and laparoscopy are distinct medical procedures that enable physicians to internally inspect different parts of the GI tract. Although they serve different purposes, each is essential for diagnosing and, in some cases, treating various medical conditions.
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
Spinal anesthetics are given during lower abdomen and limb surgeries to block sensory and motor neurons. They are administered in the mid to low lumbar regions, primarily acting on the cauda equina's nerve roots. The blockade level depends on the local anesthetic (LA) concentration. Usually, low LA concentrations are sufficient to block sensory fibers, while only high LA concentrations block motor fibers. Other factors like injection volume and speed, the patient's posture, and the drug...

