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开发和验证手术前MRI息地放射学模型,以预测膀癌的变异性组织学

Lingmin Kong¹, Yanjin Qin¹, Hui Li²

¹Department of Radiology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, People's Republic of China.

Journal of magnetic resonance imaging : JMRI

|August 20, 2025

概括

一个基于MRI的新模型,VHRisk Score (VHRiS) 准确地识别了激进的膀癌变异组织学. 这种工具有助于风险分层和预测无病生存率和治疗反应.

科学领域:

放射学
癌症学
医学成像

背景情况:

膀癌 (BCa) 具有变异性组织学 (VH) 的临床过程具有侵略性.
与预后不佳和对新辅助治疗 (NAT) 的耐药性有关.
在手术前识别VH对于定制治疗策略至关重要.

研究的目的:

开发和验证基于MRI的多参数组合模型来识别BCa中的VH.
评估该模型与无疾病生存率 (DFS) 和NAT反应的关联.

主要方法:

在四个中心对620名BCa患者的回顾性分析.
使用MRI数据 (T2W,DWI,DCE-T1W) 的VHRiskScore模型的开发.
对内部和外部数据集的模型验证;对专用DFS和NAT队列的预后价值的评估.

主要成果:

在确定VH时,VHRiS模型的准确性很高 (AUC在0. 895到0. 974之间).
低风险患者 (VHRiS ≥ 0. 863) 的寿命显著延长 (4. 20 vs 3. 08 个月).
在NAT治疗后,低风险患者的病理完整反应 (pCR) 率较高 (64%对33%).

结论:

在膀癌中,VHRiS模型是一个强大的工具.
在BCa患者中,VHRiS提供了一种潜在的风险分层和预后方法.
这种基于MRI的方法可以为BCa的个性化治疗决定提供信息.

关键词:

膀的癌症息地辐射学变种组织学

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