Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Integration of Transcriptional Signatures from Brain Tissue and Plasma Extracellular Vesicles of a Preclinical Tauopathy Mouse Model.

International journal of molecular sciences·2026
Same author

OTUD1 promotes the progession of depression through mitochondrial damage by targeting MST1/2.

Brain, behavior, and immunity·2026
Same author

Author Correction: CHIT1-positive microglia drive motor neuron ageing in the primate spinal cord.

Nature·2026
Same author

Integration of transcriptional signatures from brain tissue and plasma extracellular vesicles of a preclinical tauopathy mouse model.

bioRxiv : the preprint server for biology·2026
Same author

Serum-Derived Extracellular Vesicles as Biological Indicator of Mobility Resilience in Older Adults.

Aging cell·2026
Same author

A novel technique for monitoring Alzheimer's disease associated changes in brain-derived extracellular vesicle cargos in mouse models.

bioRxiv : the preprint server for biology·2026

相关实验视频

Updated: Sep 8, 2025

Multiplexed Analysis of Retinal Gene Expression and Chromatin Accessibility Using scRNA-Seq and scATAC-Seq
06:24

Multiplexed Analysis of Retinal Gene Expression and Chromatin Accessibility Using scRNA-Seq and scATAC-Seq

Published on: March 12, 2021

3.7K

解码贝克萨罗治疗对AD类模型小鼠大脑的影响:单细胞转录组学和染色质可访问性分析

Yi Lu1, Xuebao Wang1, Carolina Saibro-Girardi1

  • 1University of Pittsburgh.

Research square
|August 20, 2025
PubMed
概括

贝克萨罗对视网膜X受体 (RXR) 的激活调节了对大脑健康至关重要的基因网络,通过恢复平衡,可能为神经退行性疾病提供新的治疗途径.

科学领域:

  • 神经科学
  • 分子生物学
  • 基因组学

背景情况:

  • 联体激活的视网膜X受体 (RXR) 对神经发育,神经炎症和代谢至关重要.
  • 了解RXR对染色体和基因表达的影响是治疗神经退行性疾病的关键.

研究的目的:

  • 在老鼠阿尔茨海默病模型中研究RXR介导的调节机制.
  • 阐明RXR激活的表观遗传学和转录效应.

主要方法:

  • 集成的单核ATAC-seq (snATAC-seq) 和单细胞RNA-seq (scRNA-seq).
  • 通过RXR ChIP-seq验证的染色质可访问性.
  • 执行转录因子 (TF) 足迹,以映射RXR激活的调节网络.

主要成果:

  • 通过RXR信号启动的多层转录级联.
  • 揭示了涉及TF异构体激活和代谢途径诱导的RXR中心电路.
  • 贝克萨罗调节现有的TF网络而不是拆除神经元调节支架.

结论:

  • 综合的奥米克方法提供了RXR转录调节的全面分析.
关键词:
阿尔茨海默病贝克萨罗染色体的可访问性视网膜X受体单细胞转录组学转录因子足迹

更多相关视频

Assessment of Chimeric Antigen Receptor T Cell-Associated Toxicities Using an Acute Lymphoblastic Leukemia Patient-Derived Xenograft Mouse Model
06:08

Assessment of Chimeric Antigen Receptor T Cell-Associated Toxicities Using an Acute Lymphoblastic Leukemia Patient-Derived Xenograft Mouse Model

Published on: February 10, 2023

1.4K
Comprehensive Analysis of Transcription Dynamics from Brain Samples Following Behavioral Experience
08:14

Comprehensive Analysis of Transcription Dynamics from Brain Samples Following Behavioral Experience

Published on: August 26, 2014

11.8K

相关实验视频

Last Updated: Sep 8, 2025

Multiplexed Analysis of Retinal Gene Expression and Chromatin Accessibility Using scRNA-Seq and scATAC-Seq
06:24

Multiplexed Analysis of Retinal Gene Expression and Chromatin Accessibility Using scRNA-Seq and scATAC-Seq

Published on: March 12, 2021

3.7K
Assessment of Chimeric Antigen Receptor T Cell-Associated Toxicities Using an Acute Lymphoblastic Leukemia Patient-Derived Xenograft Mouse Model
06:08

Assessment of Chimeric Antigen Receptor T Cell-Associated Toxicities Using an Acute Lymphoblastic Leukemia Patient-Derived Xenograft Mouse Model

Published on: February 10, 2023

1.4K
Comprehensive Analysis of Transcription Dynamics from Brain Samples Following Behavioral Experience
08:14

Comprehensive Analysis of Transcription Dynamics from Brain Samples Following Behavioral Experience

Published on: August 26, 2014

11.8K

  • 在疾病背景下,RXR激活调节基因网络以恢复大脑平衡.