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Updated: Sep 8, 2025

Functional Reconstitution and Channel Activity Measurements of Purified Wildtype and Mutant CFTR Protein
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Functional Reconstitution and Channel Activity Measurements of Purified Wildtype and Mutant CFTR Protein

Published on: March 9, 2015

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CFTR活动增强的热力学基础

Guangyu Wang

    Research square
    |August 20, 2025
    PubMed
    概括

    三甲调节剂通过稳定核酸结合域二分化来增强囊性纤维化膜传导性调节器 (hCFTR) 的功能. NBD1和NBD2之间的可比热稳定性对于VX-770的强化,改善CFTR功能至关重要.

    关键词:
    合性合数字生物学跨领域互动最不稳定的相互作用连接物调制化的门蛋白质稳定性热力学特征热的情况

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