骨髓介质干细胞可以通过抑制胰腺恒星细胞的激活来预防慢性胰腺炎的小鼠的胰腺纤维化
Tong Jin1, Haoxuan Cheng1, Miaomiao Li1
1Department of Gastroenterology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People's Republic of China.
Journal of inflammation research
|August 20, 2025
概括
骨髓介质干细胞 (BMSC) 通过抑制激活的胰腺恒星细胞 (PSC) 来减少胰腺纤维化. 在慢性胰腺炎中,这种治疗作用可能涉及酸受体 (AhR) 和过氧体增殖剂激活受体马 (PPARγ) 信号.
科学领域:
- 胃肠病学
- 干细胞生物学
- 纤维化研究
背景情况:
- 慢性胰腺炎是一种由遗传和环境因素影响的渐进性纤维炎症.
- 胰腺星状细胞 (PSC) 的激活导致纤维化,这是CP的关键病理特征.
- 骨髓介质干细胞 (BMSC) 具有抗纤维和抗炎性质,但它们在胰腺纤维化中的作用尚不清楚.
研究的目的:
- 研究BMSC对慢性胰腺炎的治疗效果.
- 阐明BMSC调节胰腺星状细胞激活和功能的基本机制.
主要方法:
- 用Ceruletide诱导小鼠CP模型,然后进行BMSC移植.
- 组织学分析 (H&E,马森三色) 评估了胰腺损伤和纤维化.
- 在体外共同培养实验和转录组分析确定了关键的分子介质.
主要成果:
- 在体内,BMSC显著降低了胰腺病理变化和原沉积.
- 在实验室中,BMSCs抑制了PSC的激活,增殖和原分泌,同时促进了亡.
- 通过RNA测序确定了基受体 (AhR) 和过氧体增殖器激活的受体 (PPARγ) 作为潜在的媒介.
结论:
- BMSC移植有效抑制PSC激活并减轻胰腺纤维化.
- 在CP中BMSC的抗纤维作用可能由PSC中的AhR和PPARγ激活介导.
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