肺癌患者同时患有肺结核的生存预测的炎症营养生物标志物模型
Hongqi Zhou1, Zihao Zhao2, Jinhai Wang3
1Oncology Department, Guiyang Public Health Treatment Center, Guiyang, China.
Frontiers in molecular biosciences
|August 20, 2025
概括
该研究使用炎症营养标志物开发了肺癌和肺结核患者的新预后模型. 该模型准确预测存活率,并确定针对性干预的高风险个体.
科学领域:
- 癌症学
- 肺病学
- 生物标志物
- 预测模型
背景情况:
- 肺癌和结核病 (TB) 的并发症带来了独特的预后挑战.
- 现有的预后模型不能充分解决这种特定的患者群体.
- 炎症和营养标志物在预测各种疾病的结果方面具有潜力.
研究的目的:
- 开发和验证肺癌和结核病患者的多维预后模型.
- 在这个群体中评估八种炎症营养生物标志物的预后价值.
- 为风险分层提供一个工具,并指导潜在的干预措施.
主要方法:
- 对100名肺癌和结核病患者进行了回顾性研究.
- 使用八种炎症营养标志物 (NLR,PLR,SII,LMR,PNI,HALP,HRR,ALB/GLB) 作为预测剂.
- 使用LASSO回归来选择特征和Cox比例危险模型进行生存分析.
- 通过ROC曲线,C指数和校准图表与引导重新采样来评估模型性能.
主要成果:
- 最后一个模型包括糖尿病,ECOG PS,NLR,PNI,HRR和RDW.
- ECOG PS被确定为一个独立的预后因素 (HR = 1.76, p = 0. 04).
- 诺米图表显示出良好的性能 (C指数=0.71) 和优异的校准.
- 一个高风险小组 (ECOG PS ≥2和NLR>8) 显示了接近零的5年生存率.
- 在 ECOG PS 和 NLR 之间发现了显著的相互作用 (p = 0. 032).
结论:
- 这是首个结合肺癌和结核病患者的炎症营养标志物的验证预后模型.
- 该模型作为个体风险分层的定量工具.
- 这些发现支持对高风险患者进行营养干预.
更多相关视频
10:04Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
Published on: September 5, 2017
18.9K
07:42Fluorescence Assays for the Study of Mycobacterium tuberculosis Interaction with the Immune Receptor SLAMF1
Published on: February 28, 2025
568
相关概念视频
01:26Pulmonary Tuberculosis IV
196
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
196
01:31Pulmonary Tuberculosis III
438
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
438
01:29Pulmonary Tuberculosis I
321
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
321
01:28Pulmonary Tuberculosis II
339
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
339
01:28Pulmonary Tuberculosis V
236
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
236
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
407
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
407