在更年期前和更年期后妇科门诊患者中与年龄相关的阴道微生态和感染流行病学:横截面研究
Wenyu Lin1,2,3, Liying Wang1,2,3, Binhua Dong1,2,3
1Laboratory of Gynecologic Oncology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, China.
Frontiers in cellular and infection microbiology
|August 20, 2025
概括
绝经后雌激素下降会影响阴道健康,增加细菌性阴道炎 (BV) 和有氧性阴道炎 (AV),同时减少酵母感染. 需要考虑阴道微生物群,酶和代谢物的与年龄相关的变化,以获得有效的临床治疗.
科学领域:
- 妇科医生
- 微生物学
- 代谢学
背景情况:
- 绝经后雌激素缺乏会破坏阴道的微生态平衡.
- 阴道感染和微生物群变化在妇科门诊患者中很常见.
研究的目的:
- 在绝经前和绝经后妇女中调查阴道感染和微生物组成,酶和代谢物的流行病学.
- 了解与年龄相关的雌激素变化对阴道微生态的影响.
主要方法:
- 对27,346名女性 (2018-2023) 的阴道微生态数据进行横截面研究.
- 对阴道清洁,细菌密度和多样性的系统评估.
- 对20名参与者 (10名绝经前,10名绝经后) 的非向性LC-MS代谢分析.
主要成果:
- 绝经后的女性表现出较高的细菌性阴道炎 (BV) 和有氧性阴道炎 (AV),但较低的阴道炎 (VVC) 发生率.
- 在绝经后的妇女中观察到高的BV相关生物标志物和炎症标志物.
- 在更年期后的妇女中,代谢分析显示陈氧基醇酸甘氨酸结合物的增加和O- 三氨酸,形态氨酸和饮食氨酸的减少.
结论:
- 年龄显著影响阴道微生态,影响感染流行病学,微生物群,酶和代谢物.
- 临床干预必须考虑与年龄相关的雌激素变化,以有效管理阴道健康.
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