在亚洲早期发病的肺癌:一个叙事审查
1Department of Medicine, Manila Central University-FDT Medical Foundation Hospital, Caloocan, Metro Manila, Philippines.
Frontiers in oncology
|August 20, 2025
概括
早期发病的肺癌 (EOLC) 在全球范围内正在上升,亚洲占大多数病例. 年轻人的EOLC具有独特的特点,需要有针对性的研究和干预措施.
科学领域:
- 在瘤学瘤学.
- 基因组学就是基因组学.
- 流行病学 流行病学
背景情况:
- 早期肺癌 (EOLC) 的发病率,定义为50岁以下成年人的肺癌,在全球范围内正在增加.
- 亚洲占全球EOLC案件的绝大多数 (75.9%),由于区域研究有限,亚洲面临着独特的挑战.
研究的目的:
- 审查亚洲早期肺癌 (EOLC) 的流行病学,临床特征和分子特征.
- 突出了针对EOLC的专门研究和定制干预措施的需要.
主要方法:
- 在PubMed,Scopus和Web of Science进行了全面的文献搜索.
- 包括2000年至2025年4月间发表的相关文章,使用关键词如"肺癌"",早期发病"",年轻人"和"亚洲".
主要成果:
- EOLC在女性中更为普遍,通常在晚期被诊断出来,通常呈现为腺癌.
- 观察到可向基因组变化的高患病率,包括EGFR突变 (30-56.3%) 和ALK重组 (16.1-50%).
- 增加可操作的基因变异 (ROS1,RET,ERBB2) 的流行率和MUC16的过度表达,特别是在室内空气污染暴露时,被注意到. 细胞介导免疫力受损表明免疫检查点抑制剂的潜在限制.
结论:
- 亚洲EOLC的发病率不断上升,凸显了有针对性的研究的必要性,因为目前的研究主要是回顾性和单一机构的.
- 与老年人群相比,EOLC表现出不同的临床和分子特征,需要定制的诊断和治疗策略.
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