在胸癌放射治疗期间的心脏毒性和干预策略
Youjin Kong1, Chao Yang2, Lingling Xie1
1Department of Cardiology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, China.
Frontiers in oncology
|August 20, 2025
概括
辐射引起的心脏病 (RIHD) 是胸部辐射的严重并发症. 这篇评论涵盖了癌症的原因,检测,以及保护癌症幸存者的新策略.
科学领域:
- 心脏病学
- 癌症学
- 放射治疗
背景情况:
- 放射性心脏病 (RIHD) 是胸部放射治疗的一个显著的剂量限制毒性.
- 它的发病包括内皮功能障碍,氧化应激和纤维化,导致心肌病和冠状动脉疾病等多种心脏问题.
- 虽然现代技术降低了风险,但心脏毒性仍然存在,特别是在易受伤害的患者中.
研究的目的:
- 综合有关RIHD病理生理学和临床表现的当前知识.
- 审查RIHD早期检测和风险分层方面的进展.
- 讨论心脏保护策略的发展,并确定研究缺口.
主要方法:
- 对当代辐射引起的心脏病研究的综合文献综述.
- 分子机制,临床表现和诊断方法的分析.
- 评估目前和新兴的治疗干预措施.
主要成果:
- RIHD具有复杂的病理生理学,在潜伏期后表现出各种临床结果.
- 早期检测正在通过先进的成像和生物标志物得到改善, 但仍然存在挑战.
- 目前的治疗方法通常是从一般的心血管疗法中调整出来的;新的向治疗方法显示出临床前的前景.
结论:
- 了解RIHD的多面性对于治疗癌症幸存者至关重要.
- 早期检测和风险分层是改善患者结果的关键.
- 需要进一步的转化研究来开发有效的心脏保护策略.
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