在术后感染的整形外科患者中因线索利德诱导的鼻膜炎和乳头炎:病例报告
Ryan J Blake1, Benjamin M Frye1,2, Allison M Lastinger1,2,3
1Department of Orthopaedic Surgery, West Virginia University, Morgantown, West Virginia, USA.
Case reports in infectious diseases
|August 20, 2025
概括
即使短时间使用,linezolid 抗生素治疗也可能引起异常的口服副作用,如舌头胀和疼痛. 这项研究突出了典型的黑色毛发舌头表现之外的非典型反应.
科学领域:
- 传染性疾病
- 药理学
- 口腔医学
背景情况:
- 莱涅佐利德是一种有效的抗菌药物,可对抗格拉姆阳性细菌感染.
- 通常用于皮肤,骨和软组织感染.
- 已知的不良反应包括血液和神经毒性.
研究的目的:
- 报告与短期使用linezolid相关的三例不典型的口服副作用.
- 描述没有典型的黑色毛的舌头表现的口腔疼痛和光斑/乳头炎.
- 强调监测新型线索利德诱导的口服不良事件的重要性.
主要方法:
- 这三名骨科患者接受了linezolid治疗.
- 临床观察口腔症状,包括周围乳头疼痛和胀.
- 排除可能引起类似症状的共感染和并发药物.
主要成果:
- 三名患者经过10天的linezolid治疗后出现了口腔疼痛和环状乳头胀.
- 症状没有特有的黑色毛发舌头变色.
- 尽管短期治疗,但没有观察到药物毒性或中性质减退的迹象.
结论:
- 即使是短时间使用,linezolid也可以诱发泛性眼球炎和乳头炎.
- 这些口服副作用可能不同于之前报告的黑色毛舌.
- 临床医生应在线索利德治疗期间监测异常口服症状.
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