孕前的肠道微生物群失生症:机制,生物标志物和基于益生菌的干预措施
Yefang Zhao1, Bingjie Wang2, Xujing Wei3
1Department of Obstetrics, Xingtai People's Hospital, Affiliated Hospital of Hebei Medical University, Xingtai, Hebei, China.
从孕前患者移植的便微生物群改变了肠道细菌,并增加了小鼠的炎症标志物. 这表明便微生物群移植 (FMT) 可能为与孕前相关的肠道失生症提供治疗潜力.
科学领域:
- 微生物组研究 微生物组研究
- 炎症性疾病 炎症性疾病
- 生殖健康 生殖健康
背景情况:
- 孕前与肠道微生物群失调和炎症升高有关.
- 便微生物群移植 (FMT) 是调节肠道微生物群的潜在治疗策略.
- 孕前患者的FMT对宿主肠道微生物群和炎症的影响需要研究.
研究的目的:
- 研究便微生物群移植 (FMT) 对肠道微生物群组成的影响.
- 为了评估FMT对血清炎症因子的影响,在预先怀孕的小鼠模型中.
- 探索FMT在孕前的治疗潜力.
主要方法:
- 建立了一个小鼠模型,用四组:对照组,抗生素治疗组,正常微生物种移植组 (NT) 和孕前症微生物种移植组 (PET).
- 使用三重抗生素治疗方案诱导了肠道微生物群的枯竭.
- 便微生物群移植是使用健康孕妇 (NT) 和严重预先孕患者 (PET) 的样本进行的.
- 16S rRNA测序分析了便微生物群组成,并测量了血清炎症标志物 (LPS,TNF-α,IL-6).
主要成果:
- 与其他组相比,PET组表现出肠道微生物组成的显著变化.
- 在PET组中丰富的种类包括Coprococcus,Bacillales和Staphylococcus.
- 在PET组中,血清中脂聚糖 (LPS),瘤缩因子-α (TNF-α) 和互白素-6 (IL-6) 的水平显著升高.
结论:
- 便微生物群的移植与来自孕前患者的细菌诱导显著的肠道微生物群变化和小鼠的全身炎症.
- 这些发现突显了肠道微生物群失生症和产前炎症炎症过程之间的联系.
- 通过调节肠道微生物群和炎症,FMT显示出治疗预孕的潜力.
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