估计的脉冲波速度作为高血压中白蛋白尿的潜在预测因素
Xianghui Zeng1, Chunqing Xiao2, Wenqing Xu2
1Department of Cardiology, Ganzhou Hospital of Traditional Chinese Medicine, Ganzhou, Jiangxi, China.
Frontiers in medicine
|August 20, 2025
概括
估计的脉冲波速度 (ePWV) 与高血压患者的白蛋白尿有关. 较高的ePWV表明早期损伤的风险增加,这表明ePWV可以评估功能.
科学领域:
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學.
- 高血压研究 高血压研究
背景情况:
- 动脉硬度,通过增加脉冲波速度 (PWV) 表示,是高血压中目标器官损伤的关键标记.
- 白蛋白尿症意味着早期的功能障碍,但其与估计的脉冲波速度 (ePWV) 的联系需要验证.
- 高血压管理需要了解动脉硬及其对功能的影响.
研究的目的:
- 调查高血压患者估计脉冲波速度 (ePWV) 和白膜尿之间的关联.
- 为了确定ePWV和albuminuria之间的剂量反应关系.
- 探索ePWV作为评估高血压患者早期损伤的潜在工具.
主要方法:
- 从2024年7月到2025年4月,回顾性招募761名高血压患者.
- 使用心压和腹压血压和年龄计算ePWV的计算.
- 通过测量棒测试检测白蛋白尿,通过逻辑回归和受限立方线 (RCS) 分析进行关联和剂量反应评估.
主要成果:
- 观察到19.6%的阳性白色素尿率.
- 较高的ePWV (≥10.74 m/s) 与白蛋白尿明显相关 (OR=2.79).
- 每增加1m/s的ePWV与42%的白蛋白尿风险增加相关 (OR=1.42),显示出线性剂量反应关系.
结论:
- 估计的脉冲波速度 (ePWV) 独立地与高血压患者的白蛋白尿有关.
- 线性剂量反应关系表明动脉硬是早期损伤的危险因素.
- ePWV可以作为一种简单的,非侵入性的工具,用于高血压中初级功能评估.
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