Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Neurulation01:30

Neurulation

42.5K
Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
42.5K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Reply: Stem cell-based embryo models: scientific promise clashes with ethical reality.

Human reproduction (Oxford, England)·2026
Same author

Ultra-High-Velocity Penetration Performance of Lightweight W-Based Ceramic Alloy Rod Penetrator Against Concrete Targets.

Materials (Basel, Switzerland)·2026
Same author

Base-Catalyzed Diversity-Orientated Synthesis of Tetra-/Dihydrothiophenecarboxamides and Preliminary Evaluation as Antifungal Agents.

The Journal of organic chemistry·2026
Same author

MAPK-driven glioma progression and reprogramming of the tumor-associated immune response.

Neuro-oncology·2026
Same author

SMPD3 suppresses oligodendroglioma growth via dual autocrine-paracrine roles.

Communications biology·2026
Same author

Bioengineering gradients for controlled embryo and organ modeling.

Current opinion in biomedical engineering·2026

相关实验视频

Updated: Sep 8, 2025

Generation of iPSC-derived Human Brain Organoids to Model Early Neurodevelopmental Disorders
07:40

Generation of iPSC-derived Human Brain Organoids to Model Early Neurodevelopmental Disorders

Published on: April 14, 2017

20.8K

神经原始体作为小头症的新型致病机制

Rami Yair Tshuva, Jeyoon Bok, Mio Nonaka

    bioRxiv : the preprint server for biology
    |August 20, 2025
    PubMed
    概括

    NDE1基因的丧失会影响早期的大脑发育,通过破坏前细胞和前脑区域化,导致小头. 恢复ERK信号部分纠正了这些发育缺陷.

    科学领域:

    • 神经科学
    • 发育生物学
    • 遗传学

    背景情况:

    • 包括小头症在内的神经发育障碍的遗传和分子基础不明.
    • NDE1基因与小头症有关,但其在大脑发育中的确切作用尚不清楚.

    研究的目的:

    • 通过器官和小鼠模型研究NDE1在人类大脑发育中的功能.
    • 阐明NDE1损失导致小头症和前脑异常的分子机制.

    主要方法:

    • 使用人类大脑器官和NDE1淘汰小鼠模型.
    • 分析了原始细胞的身份,细胞分裂的持续时间和区域模式.
    • 研究了ERK信号通路的作用.

    主要成果:

    • 在人类大脑器官和小鼠模型中,NDE1损失破坏了原始体身份和延长了线粒分裂.
    • 导致神经元前细胞的尾部转移, 改变前脑区域模式.
    • 在NDE1淘汰模式中观察到异常的ERK信号,其下游激活部分恢复了面PAX6表达.

    结论:

    • NDE1是早期人类大脑区域化的关键调节者.
    • 通过涉及原始细胞身份和ERK信号的机制,NDE1功能的破坏导致小头症的结构异常.

    更多相关视频

    Live Imaging of Mitosis in the Developing Mouse Embryonic Cortex
    09:25

    Live Imaging of Mitosis in the Developing Mouse Embryonic Cortex

    Published on: June 4, 2014

    15.4K
    A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations
    08:22

    A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

    Published on: December 1, 2017

    8.7K

    相关实验视频

    Last Updated: Sep 8, 2025

    Generation of iPSC-derived Human Brain Organoids to Model Early Neurodevelopmental Disorders
    07:40

    Generation of iPSC-derived Human Brain Organoids to Model Early Neurodevelopmental Disorders

    Published on: April 14, 2017

    20.8K
    Live Imaging of Mitosis in the Developing Mouse Embryonic Cortex
    09:25

    Live Imaging of Mitosis in the Developing Mouse Embryonic Cortex

    Published on: June 4, 2014

    15.4K
    A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations
    08:22

    A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

    Published on: December 1, 2017

    8.7K