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Updated: Sep 8, 2025

Genetic Manipulation of Cerebellar Granule Neurons In Vitro and In Vivo to Study Neuronal Morphology and Migration
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在Mecp2-null新皮质中异常周神经网络的调节

Ashis Sinha, Angelica M Kowalchuk, Nasim Khatibi

    bioRxiv : the preprint server for biology
    |August 20, 2025
    PubMed
    概括

    雷特综合征 (RTT) 涉及由于早发性周神经网络 (PNN) 的形成而导致大脑可塑性的早期关闭. Mecp2-null星球细胞推动了PNN的发展,为RTT提供了新的治疗点.

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    In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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