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Updated: Sep 8, 2025

Author Spotlight: Integrating BRET-Based Assays and Rare Mutation Analysis to Decipher RAF Kinase Regulation in Live Cells
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Published on: March 1, 2024

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ARAF,BRAF和CRAF复合物的特征和抑制剂敏感性

Emre Tkacik1,2,3, Dong Man Jang1,2, Kayla Boxer1

  • 1Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

bioRxiv : the preprint server for biology
|August 20, 2025
PubMed
概括

在RAF,BRAF和CRAF异型中,RAF抑制剂的有效性各不相同. 类型II抑制剂对CRAF有作用,但对ARAF没有作用,影响癌症治疗的发展.

关键词:
一个 RAF 激酶合作性药物作用酶动力学光共振能量转移 (FRET)抑制机制进行X射线结晶学

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