视觉皮层中的试验对试验数变化的全球和本地来源
Anna J Li1, Ziyu Lu2, Alexander E Ladd1
1Department of Neurobiology and Biophysics, University of Washington, Seattle, WA, USA.
bioRxiv : the preprint server for biology
|August 20, 2025
概括
视觉皮层的神经活动的变化受全球大脑信号的影响, 不仅仅是局部活动或行为. 这些全球因素解释了视觉皮层神经元的试验差异,
科学领域:
- 神经科学
- 计算神经科学
- 系统神经科学
背景情况:
- 感觉神经元反应表现出试验对试验的变化,神经活动,兴奋和运动的贡献.
- 这种变异性代表噪声与底层信号的程度尚不清楚.
- 全球大脑活动模式可能解释视觉皮层神经元反应的额外变化.
研究的目的:
- 调查全球皮质活动模式对小鼠初级视觉皮层 (V1) 峰值数量的试验变异性的贡献.
- 区分全球活动的解释力与V1反应的行为因素.
- 确定局部电路与非局部源的V1变化程度.
主要方法:
- 在被动图像查看过程中使用Neuropixels 2.0探针记录小鼠V1的神经活动.
- 同时记录前带膜区域 (ACA) 或背皮层广场信号的行为数据和神经活动.
- 通过降低等级回归来划分V1数的可解释变异性.
主要成果:
- 当地共享的活动模式解释了超过Poisson峰值的变化,独立于行为或全球活动.
- 全球皮质活动显著预测了比行为因素更多的V1数变化.
- 行为因素解释了很少的独特变化,是全球可预测V1活动的子空间.
- 即使没有明显的行为,ACA的光遗传干扰也影响了V1的活动,ACA模式也预测了V1的变化.
结论:
- 来自其他皮层区域的全球共享因素对V1数的变化有很大影响.
- 一小部分的共享可变性仅限于局部V1电路.
- 全球大脑状态,特别是像ACA这样的区域, 在调节视觉皮层处理方面发挥着重要作用.
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