在正在发育的婴儿肠道微生物群中,可利巴基因非常普遍
Shira Levy1, Kathryn E McCauley2, Rachel Strength1
1Clinical Microbiome Unit, Laboratory of Host Immunity and Microbiome, Division of Intramural Research, National Institute of Allergy and Infectious Disease, National Institute of Health, Bethesda, MD.
medRxiv : the preprint server for health sciences
|August 20, 2025
概括
在婴儿中产生可利巴克的肠道细菌 (pks+) 是常见的,这表明早期携带是正常的. 需要更多的研究来了解这种细菌如何增加晚年结肠直肠癌的风险.
科学领域:
- 微生物学
- 胃肠病学
- 癌症学
背景情况:
- 携带 * pks * 基因组岛的可利巴克产生细菌与结直肠癌的发展有关.
- 早期肠道微生物组的组成对长期健康至关重要.
- 在生命早期和随后的癌症风险中, *pks+* 细菌的作用尚不清楚.
研究的目的:
- 调查婴儿中产生大肠杆菌 (*pks+*) 的细菌的流行情况.
- 评估生命早期*pks+*细菌携带与结直肠癌风险之间的潜在联系.
主要方法:
- 在婴儿肠道微生物组中对*pks+*细菌的流行率研究.
- 在生命的头两年内对pks+*细菌携带的分析.
主要成果:
- 在50%以上的研究婴儿中观察到极高的pks+细菌患病率.
- 在生命早期的微生物组发育过程中携带*pks+*细菌似乎是常见的现象.
结论:
- 早期携带可利巴克产生的 (*pks+*) 细菌可能是肠道微生物组发育的正常方面.
- 需要进一步研究以确定pks+* 细菌携带可能导致突变和增加结直肠癌风险的具体条件.
相关概念视频
Bacterial Flora of the Large Intestine
640
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
640
Anatomy of the Intestines
73.8K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
73.8K
Bacterial Phylum Firmicutes
142
Firmicutes is a diverse phylum of Gram-positive bacteria characterized by a low GC content in their genomes. This phylum includes organisms with monoderm or diderm cell envelopes, highlighting a complex evolutionary history. Firmicutes comprises several major orders, including Lactobacillales, Clostridiales, and Bacillales, which exhibit remarkable diversity in their morphology, metabolism, and ecological roles.The order Lactobacillales includes lactic acid bacteria, which are fermentative...
142
Bacterial Phylum Actinobacteria
109
Coryneform bacteria are gram-positive, aerobic, nonmotile rods that exhibit irregular, club-shaped, or V-shaped arrangements. Their V-shape results from snapping division, where the inner cell wall layer forms the cross-wall, while the outer layer remains intact until it ruptures on one side, causing the daughter cells to bend away.The primary genera are Corynebacterium and Arthrobacter. Corynebacterium includes diverse species, ranging from saprophytes to pathogens like Corynebacterium...
109
Development of Antibiotic Resistance
197
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
197


