根据感染前症状和功能状况的长期COVID风险:对我们所有人研究计划数据的回顾性队列研究
medRxiv : the preprint server for health sciences
|August 20, 2025
概括
感染前存在的症状和较差的心理健康增加了长期的COVID风险. 长期的COVID是一个显著的健康变化,即使对于那些有先前疾病的人来说,也强调了功能状态评估的必要性.
科学领域:
- 医学研究
- 公共卫生
- 流行病学
背景情况:
- 超过700万美国成年人经历了长期的COVID,COVID-19后持续的健康问题.
- 指导方针建议在长期COVID诊断中包括功能状态,但证据有限.
- 这项研究调查了影响长期COVID发展和功能状态评估可行性的感染前因素.
研究的目的:
- 根据感染前的症状和功能状况,探索长期COVID的调整几率.
- 通过电子健康记录评估感染前功能状态的可行性.
- 通过了解风险因素,提供长期COVID的诊断标准.
主要方法:
- 使用我们所有人的CDR 7.0数据库进行回顾性队列研究.
- 包括有COVID-19病史的美国成年人,分析到2022年7月的健康记录和调查数据.
- 检查感染前 (5 年前) 的症状和功能状况,并对共变量进行调整.
主要成果:
- N = 65,464名参与者符合纳入标准; 40,655人出现长期COVID症状.
- 长期COVID的增加与感染前较低的自我评估心理健康 (AOR=1.14) 和较高的症状负担相关.
- 在单个感染前症状,自我评估的身体能力或记录的功能障碍和长期COVID几率之间没有发现显著的关联.
结论:
- 较高的疾病前症状负担和较低的心理健康评估与长期COVID的可能性增加有关.
- 长期的COVID意味着健康和功能从基线显著下降,即使有先前的条件.
- 使用协调的电子健康记录可用于估计感染前的功能状态,有助于长期的COVID诊断.
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