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Updated: Sep 8, 2025

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
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基于zolactam 的 Gli 抑制剂:合成和结构分析

Marianna Haddad1, Charles Wilber1, Jordan MacQueen1

  • 1Department of Chemistry and Biochemistry, Loyola University Chicago, Chicago, Illinois 60660, United States.

ACS medicinal chemistry letters
|August 20, 2025
PubMed
概括

研究人员开发了TPPB,一种新的zolactam衍生 Gli 抑制剂,针对癌症的进展. 这种Smo独立的化合物在基底细胞癌模型中显示出抗瘤活性,从而提供了新的治疗策略.

关键词:
它们刺信号通道基底细胞癌zolactam的使用情况一种抑制剂蛋白质激酶C

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