相关实验视频

Updated: Apr 8, 2026

DNA-affinity-purified Chip DAP-chip Method to Determine Gene Targets for Bacterial Two component Regulatory Systems
12:24

DNA-affinity-purified Chip DAP-chip Method to Determine Gene Targets for Bacterial Two component Regulatory Systems

Published on: July 21, 2014

16.9K

从DNA编码图书馆屏幕中发现E3连接酶STUB1/CHIP的小分子连接体

Simon C C Lucas1, Alexander G Milbradt2, Jason Breed2

  • 1Hit Discovery, Discovery Sciences, R&D, AstraZeneca, Cambridge CB2 0AA, U.K.

ACS medicinal chemistry letters
|August 20, 2025
PubMed
概括

研究人员发现了强大的小分子配体,用于STIP1同类和含有蛋白质1的U盒 (STUB1),也称为CHIP. 化合物5是发现的最强大的CHIP连接体,作为开发新分子工具的基础.

关键词:
阵列这里是CHIP.美国E3 连接酶美国进行重组一个STUB

更多相关视频

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines05:33

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines

Published on: November 9, 2020

10.1K
In Vitro Analysis of E3 Ubiquitin Ligase Function06:06

In Vitro Analysis of E3 Ubiquitin Ligase Function

Published on: May 14, 2021

5.4K

相关概念视频

iChip01:24

iChip

The cultivation of environmental microorganisms has long been hindered by the inability to replicate complex native conditions in vitro. The isolation chip (iChip) addresses this limitation by facilitating the growth of previously uncultivable microorganisms through in situ incubation. Designed for high-throughput microbial cultivation, the iChip comprises hundreds of microchambers, each capable of housing a single microbial cell. These microchambers are loaded with a mixture of molten agar and...
74