针对系统性硬化症的炎症,纤维化和血管功能障碍:饮食和补充和替代医学的作用
Veronica Balbuena Hurtado1,2, Monique Hinchcliff1,3, Navya Murugesan1
1Yale School of Medicine, Department of Medicine, Section of Rheumatology, Allergy & Immunology, New Haven.
Current opinion in rheumatology
|August 20, 2025
概括
改变饮食和补充疗法可能有助于控制全身性硬化症 (SSc) 的症状. 虽然有希望,但需要进一步的研究来证实功能性食物和替代药物的有效性.
科学领域:
- 关节病学
- 营养科学
- 综合医学
背景情况:
- 系统性硬化症患者经常询问饮食和补充疗法.
- 功能性食物和补充和替代医学 (CAM) 正在作为SSc的辅助治疗方法进行研究.
研究的目的:
- 审查有关饮食干预,功能性食品和SSc管理的CAM的现有文献.
- 总结这些方法的有效性和安全性的现有证据.
主要方法:
- 对研究饮食方法的文献搜索 (例如,低FODMAP,地中海,性饮食).
- 对补充剂 (例如,omega-3,curcumin),草药,局部药物和维生素的研究进行审查.
- 对减轻症状,微生物群调节和抗炎作用的证据分析.
主要成果:
- 低FODMAP,地中海和性饮食显示出在小样本尺寸的SSc中减少症状和微生物群调节的潜力.
- 富含酸盐和抗氧化剂的补充剂,包括omega-3脂肪酸,可以减少炎症和氧化应激.
- 在临床前研究中,黄素等草药具有抗纤维素的特性;常用的是局部剂和维生素,但缺乏可靠的临床试验.
结论:
- CAM,饮食干预和功能性食物显示出对SSc的支持疗法的潜力.
- 需要更多高质量的临床研究来确定SSc管理中的这些干预措施的确证据.
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