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Clinical Applications of Epidermal Stem Cells

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...

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Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability

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多功能微针贴片可清除ROS,促进伤口愈合

Mahshid Kharaziha^1,2, Sahar Salehi², Mahshid Shokri¹

¹Department of Materials Engineering, Isfahan University of Technology, Isfahan, 84156-83111, Iran.

Advanced healthcare materials

|August 20, 2025

概括

这项研究开发了一种微针阵列,可减少慢性伤口的炎症和痕. 这种新剂通过吸收反应性氧物种 (ROS) 和调节免疫反应来促进愈合.

关键词:

在 ROS 清理中素功能化颗粒没有飞行 I siRNA 免疫调节性质微针贴片伤口愈合

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科学领域:

生物材料科学
复原医学
创伤治愈研究

背景情况:

由于炎症,纤维化和过度反应性氧物种 (ROS),慢性伤口的愈合延迟.
不正常的伤口微环境阻碍了组织的修复,并促进了痕.
目前的治疗方法往往无法解决阻碍慢性伤口愈合的复杂因素.

研究的目的:

开发用于慢性伤口治疗的多功能微针阵列 (MNA).
将反应性氧物种 (ROS) 清除与加速组织形成相结合.
研究MNA对伤口愈合的免疫调节作用.

主要方法:

氨酸甲酸 (HaMA) 微针阵列的制造.
用无飞行I (Flii) siRNA加载的氨酸功能化聚 (β-氨基) -氨酸 (APA) 颗粒加载阵列.
使用HaCaT细胞的体外研究和使用老鼠慢性伤口模型的体内研究.

主要成果:

通过氧化物 (NO) 输送,SiRNA- APA载的MNA显示出增强的ROS清除能力.
观察到抑制Flii表达和降低促炎细胞因子 (TNF-α,IL6).
在老鼠中通过皮肤施用MNA可缓解痕形成,并通过减少炎症促进伤口愈合.

结论:

开发的 siRNA- APA 载荷的 HaMA MNA 具有 ROS 清除和免疫调节的特性.
这种MNA显示出有效治疗慢性伤口的巨大潜力.
这些发现为先进的伤口包应用提供了有前途的见解.