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相关概念视频

Carbon Skeletons01:12

Carbon Skeletons

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Life on Earth is carbon-based, as all macromolecules that make up living organisms contain carbon atoms. All organic compounds have a carbon backbone. Each carbon atom is tetravalent and can bond with four other atoms, making it an extraordinarily flexible component of biological molecules. Because carbon’s valence electrons are stable, it rarely becomes an ion. As the carbon chain increases in length, structural modifications such as ring structures, double bonds, and branching side...
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Overview of Nitrogen Metabolism01:20

Overview of Nitrogen Metabolism

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Nitrogen is a very important element for life because it is a major constituent of proteins and nucleic acids. It is a macronutrient, and in nature, it is recycled from organic compounds and stored in the form of  ammonia, ammonium ions, nitrate, nitrite, or  nitrogen gas by many metabolic processes. Many of these metabolic processes are carried out only by prokaryotes.
The largest pool of nitrogen available in the terrestrial ecosystem is gaseous nitrogen (N2) from the air, but this...
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RNA Editing02:23

RNA Editing

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RNA editing is a post-transcriptional modification where a precursor mRNA (pre-mRNA) nucleotide sequence is changed by base insertion, deletion, or modification. The extent of RNA editing varies from a few hundred bases, in mitochondrial DNA of trypanosomes, to a just single base, in nuclear genes of mammals. Even a single base change in the pre-mRNA can convert a codon for one amino acid into the codon for another amino acid or a stop codon. This type of re-coding can significantly affect the...
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Naming Skeletal Muscles01:19

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The naming of the approximately 700 muscles in the human body is based on a set of criteria designed to provide descriptive information about each muscle, making it easier to identify and remember them.
The key factors used in naming muscles include:
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Bone Remodeling01:40

Bone Remodeling

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Inorganic Nitrogen Assimilation01:22

Inorganic Nitrogen Assimilation

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Nitrogen is an essential element in biological systems, forming a crucial component of proteins, nucleic acids, and other cellular constituents. Many bacteria and archaea acquire nitrogen in the form of nitrate (NO₃⁻) or ammonia (NH₃), which are then assimilated into biomolecules through specific enzymatic pathways.Assimilatory Nitrate ReductionWhen nitrate enters the cell, it undergoes a two-step reduction process known as assimilatory nitrate reduction. Initially, the enzyme...
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相关实验视频

Updated: Sep 10, 2025

Construction of a Realistic, Whole-Body, Three-Dimensional Equine Skeletal Model using Computed Tomography Data
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Construction of a Realistic, Whole-Body, Three-Dimensional Equine Skeletal Model using Computed Tomography Data

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基于原子操纵的骨编辑

Linlin Ding1, Yang Fan1, Hongjian Lu1,2

  • 1State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, Jiangsu 210093, China. hongjianlu@nju.edu.cn.

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PubMed
概括
此摘要是机器生成的。

原子编辑 (N-原子编辑) 通过实现新的分子转换来推进合成化学. 这篇综述涵盖了药物化学和材料科学的最新突破和应用.

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科学领域:

  • 合成化学
  • 有机化学
  • 医学化学

背景情况:

  • 原子在生物活性分子和合成构件中至关重要.
  • 由于其实用性,原子编辑 (N-原子编辑) 已经获得了突出地位.
  • 最近的进展扩大了N原子编辑的范围和应用.

研究的目的:

  • 提供N原子编辑方法的全面概述.
  • 讨论机械的见解和历史的发展.
  • 突出合成生物活性分子和材料的应用.

主要方法:

  • 对N原子编辑技术的最新文献的审查.
  • 详细讨论机械路径.
  • 在药物化学和材料科学中的应用分析.

主要成果:

  • 在过去五年中,在新的N原子编辑方法方面取得了重大进展.
  • 展示N原子编辑在各种领域的变革潜力.
  • 合成和修改复杂分子的说明性例子.

结论:

  • N原子编辑是一个强大的工具,应用范围不断扩大.
  • 机理学理解为未来的研究提供了概念工具.
  • 概述了N原子编辑的未来前景和挑战.