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Updated: Sep 10, 2025

A Method for Screening and Validation of Resistant Mutations Against Kinase Inhibitors
12:40

A Method for Screening and Validation of Resistant Mutations Against Kinase Inhibitors

Published on: December 7, 2014

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在活体中通过一般控制控制瘤生长 非可抑制的2个向剂 结果来自激酶激活

Feven Tameire1, Paulina Wojnarowicz2, Crissy Dudgeon1

  • 1HiberCell, Inc., Boston, MA, United States.

Molecular cancer therapeutics
|August 20, 2025
PubMed
概括

低剂量的GCN2激活剂,而不是抑制剂,通过激活综合应激反应来降低瘤生长. 这一意想不到的发现影响了针对GCN2的癌症疗法的临床开发.

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