一种被低估的病原体:
Brooks I Mitchell1,2, John E Markantonis3
1Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Journal of clinical microbiology
|August 20, 2025
概括
越来越多的非二菌Corynebacterium物种被认为是引起各种感染的病原体,从血流到设备相关的. 对于临床微生物学实验室来说,使用矩阵相关的激光脱离/离子化飞行时间质谱的准确识别至关重要.
科学领域:
- 医学微生物学
- 传染性疾病
- 临床诊断
背景情况:
- 从历史上看,除C. diphtheriae外的Corynebacterium物种被认为是非致病的.
- 近几十年来,导致各种感染的致病性非二菌Corynebacterium物种的增加.
- 这些细菌与特定的临床场景和解剖部位有关.
研究的目的:
- 突出非二菌Corynebacterium物种的新兴致病作用.
- 强调在临床微生物学中准确识别和报告的重要性.
- 讨论MALDI-TOF MS在识别这些生物中的有用性.
主要方法:
- 临床病例和微生物学研究的文献综述.
- 与特定的Corynebacterium物种相关的感染类型的分析.
- 诊断方法的讨论,包括MALDI-TOFMS.
主要成果:
- 导致血流和骨科感染.
- C. macginleyi和C. otitidis与眼睛和耳朵感染有关.
- C. propinquum/pseudodiphtheriticum 导致肺炎;C. urealyticum 导致囊炎;C. kroppenstedtii 与乳腺炎有关.
- 皮肤疾病如红与C. aurimucosum/minutissimum有关.
- 生物膜形成导致与器件相关的感染 (导管,分流器,假肢).
结论:
- 非二菌Corynebacterium物种是需要临床意识的重要病原体.
- 优化实验室识别,特别是MALDI- TOFMS,对于患者的护理至关重要.
- 准确的识别有助于适当治疗和管理与Corynebacterium相关的感染.
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