相关实验视频
Updated: May 2, 2026

07:48
An Orthotopic Bladder Cancer Model for Gene Delivery Studies
Published on: December 1, 2013
12.6K
在非肌肉侵入性膀癌中BCG不耐受- 一个系统性审查
Claris Oh1, Georgia Bourlotos1,2, Michael O'Callaghan1,3,4
1College of Medicine and Public Health, Flinders University, Adelaide, Australia.
ANZ journal of surgery
|August 20, 2025
概括
在非肌肉侵袭性膀癌患者中,BCG不耐受导致12. 8%的患者停止治疗. 制定管理副作用的策略对于治疗成功至关重要.
科学领域:
- 尿道病学
- 癌症学
- 临床试验
背景情况:
- 进行内镜切除是局部膀癌的标准.
- 肠道 Calmette-Guerin (BCG) 是高度非肌肉侵入性膀癌 (NMIBC) 的黄金标准.
- 30-40%的NMIBC患者由于缺乏反应,复发或不耐受而无法接受BCG治疗.
研究的目的:
- 在成年NMIBC患者中确定BCG不耐受性的发生率和原因.
- 分析与NMIBCBC治疗相关的断药率.
主要方法:
- 控制试验的Embase,MEDLINE和Cochrane中央注册表的系统审查 (1974-2023年).
- 包括28项英语研究,报告了NMIBC患者的BCG中止率和原因.
- 数据提取遵循系统审查和元分析 (PRISMA) 的优先报告项目指南.
主要成果:
- 由于不耐受性而导致的BCG断药率在0%至52%之间,估计总结比例为12. 8%.
- 在研究设计中观察到显著的异质性.
- 断药率取决于剂量 (3. 3% 与 20%) 并因BCG菌株而异 (康纳特:21.1%,帕斯图尔:2%).
结论:
- 在NMIBC患者中,BCG不耐受导致平均断药率为12. 8%.
- 停止治疗会增加疾病进展或复发的风险.
- 为了改善患者的治疗结果,需要采取缓解BCG不耐受症的策略.
相关概念视频
Inflammatory Bowel Disease V: Surgical Management
917
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Here are some common surgical interventions for IBD:
917
Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care
434
A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...
434
Urinary Tract Calculi I: Introduction
1.1K
Renal calculi, or kidney stones, are solid deposits of minerals and salts formed inside the kidneys. In medical terminology, "calculus" refers to the stone itself, while "lithiasis" describes the process of stone formation. Depending on their location within the urinary system, these stones may be classified as either urolithiasis, when situated within the urinary tract, or nephrolithiasis, when located within the kidneys. Each term signifies the specific impact of the stone.Predisposition...
1.1K
Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations
860
Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...
860
Urinary Tract Calculi III: Medical Management
400
The diagnosis of renal calculi involves several imaging techniques, including non-contrast CT scans and ultrasound. These methods help visualize kidney stones, assess their size and location, and detect possible obstructions. Additionally, Measuring urine pH is useful for diagnosing specific stone types, such as struvite (alkaline pH) and uric acid stones (acidic pH). Cystine stones are primarily linked to cystinuria, a genetic condition. A urinalysis helps detect blood in the urine (hematuria)...
400
Urinary Tract Calculi VI: Surgical Management
1.0K
Procedures for Kidney StonesMedical intervention is necessary when kidney stones or renal calculi are too large to pass spontaneously (typically greater than 5 millimeters) when stones are accompanied by symptomatic infection (such as fever or pyelonephritis), when they impair kidney function, or when they cause persistent symptoms like severe pain, nausea, or urinary retention. Additionally, patients with only one kidney or those who cannot be treated with medical management also require...
1.0K

