由前额皮层形态预测训练和tDCS诱导的通用学习
Shane E Ehrhardt1, Yohan Wards1, Thomas B Shaw2,3
1School of Psychology, The University of Queensland, McElwain Building, Campbell Road, St Lucia, 4072, QLD, Australia.
Cerebral cortex (New York, N.Y. : 1991)
|August 20, 2025
概括
结合脑部刺激与认知训练可以改善执行功能. 个体大脑解剖学, 特别是皮质厚度, 预测这种干预对提高任务性能有多有效.
科学领域:
- 神经科学
- 认知心理学
- 神经成像
背景情况:
- 脑部刺激,特别是间直流刺激 (tDCS) 是一个有前途的干预措施来增强执行功能.
- 优化tDCS疗效需要了解个体差异 (如皮质形态) 对干预结果的影响.
研究的目的:
- 调查多次多任务训练和前额tDCS对绩效效益的综合影响.
- 确定个人皮质形态如何预测结合tDCS和认知训练后认知表现的改善.
主要方法:
- 178名参与者完成了7次特斯拉MRI扫描.
- 参与者通过在线前额头tDCS (1mA或虚拟) 进行多次多任务训练.
- 在干预之前和之后,认知任务组评估了受过训练和未受训练任务的表现.
主要成果:
- 在多任务训练中向左或右前额叶皮层施加1 mA tDCS, 增强转移到视觉搜索任务.
- 在 1 mA tDCS 组的具有挑战性的视觉搜索任务中,阳极下方的皮层厚度预测了反应时间的改善.
- 在假刺激或对照训练组中没有观察到皮层厚度与性能之间的关系.
结论:
- 个人解剖学差异,特别是皮质厚度,在与认知训练相结合时显著调节tDCS的有效性.
- 神经解剖学特征可以预测通用性能增长,强调个性化方法在脑刺激干预中的重要性.
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