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转变无菌性皮肤炎管理:益生菌作为免疫调节的游戏改变者 - 一个双盲,安慰剂控制的临床试验

Caterina Mariarosaria Giorgio¹, Gaetano Licata², Raffaele Sorbo³

¹From the Dermatology Unit, Department of Mental and Physical Health and Preventive Medicine, University of Campania Luigi Vanvitelli, Naples, Italy.

Dermatitis : contact, atopic, occupational, drug

|August 20, 2025

概括

一种高剂量的益生菌配方显著改善了亚托皮炎 (AD) 的症状,并减少了炎症. 这项研究表明益生菌可能是阿尔茨海默病患者有益的辅助疗法.

科学领域:

免疫学
微生物学
皮肤病学

背景情况:

无菌性皮肤炎 (AD) 是一种慢性炎症性皮肤疾病,与免疫调节失调和肠道微生物群失衡有关.
阿尔茨海默病严重影响患者的生活质量,导致,,湿疹病变和心理困扰.
人们越来越认识到肠道失调是AD病变的一个因素,突出显示了肠道微生物群中的潜在治疗点.

研究的目的:

调查高剂量多菌株益生菌配方 (DSF配方®) 在中度至重度亚托皮炎的成年人中的疗效.
评估益生菌补充剂对阿尔茨海默病严重程度和关键免疫调节标志物的影响.

主要方法:

这是一项为期60天的双盲随机化,安慰剂对照试验,涉及80名阿尔茨海默症成年患者.
参与者接受了DSF配方®或安慰剂.
使用SCORAD,EASI和DLQI得分测量临床结果;通过量化IL-4,IL-10和TGF-β细胞因子水平来评估免疫变化.

主要成果:

与安慰剂相比,DSF Formulation®显著降低了SCORAD,EASI和DLQI得分 (P< 0. 05).
益生菌治疗导致促炎IL-4水平显著下降.
在益生菌组中观察到抗炎IL-10和TGF-β水平的显著增加 (P < 0. 05),表明免疫耐受性转变.

结论:

作为一种有效的辅助治疗,DSF Formulation® 显示出其潜力.
这种益生菌成分似乎调节了肠道微生物群,并促进了阿尔茨海默病患者的抗炎免疫反应.
需要进一步的研究来证实长期效应,并优化阿尔茨海默病治疗的益生菌策略.

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