相关实验视频
Updated: Sep 10, 2025

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy
Published on: February 21, 2025
在炎症性肠道疾病中与肉相关的死亡率增加:长期前性队列研究
Qian Zhang1, Haoxi Liu1, Si Liu1
1Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University; State Key Laboratory of Digestive Health; National Clinical Research Center for Digestive Diseases; Beijing, 100050, China.
在老年炎症性肠道疾病 (IBD) 患者中,肌肉损失显著增加长期死亡风险. 早期的肉症评估有助于预测这些人的预后.
科学领域:
- 老年学
- 胃肠病学
- 临床医学
背景情况:
- 炎症性肠道疾病 (IBD) 的老年人患病率增加.
- 在老年IBD患者中, Sarcopenia是常见的,并且与不良结果有关.
- 萨科佩尼亚对IBD患者的长期死亡率的影响仍未得到充分研究.
研究的目的:
- 在预期的一组老年IBD患者中研究皮病与全因死亡率之间的关联.
- 确定肉病状况是否可以帮助该人群的长期预后风险分层.
主要方法:
- 对4966名IBD患者进行前性队列研究 (平均年龄为56. 9岁).
- 使用欧洲老年人肉症工作组2 (EWGSOP2) 标准进行评估.
- 使用多变量Cox比例危险模型分析的全因死亡率作为主要结果.
主要成果:
- 14. 6% 的患者可能患有肉眼,0. 7% 的患者确诊患有肉眼.
- 在14. 6年的随访期间,11. 4%的患者死亡.
- 可能的肉与47%的死亡风险增加有关 (HR=1. 47),确定的肉与140%的死亡风险增加有关 (HR=2. 40).
结论:
- 在老年IBD患者中,可能和确诊的肉都是长期死亡的重要风险因素.
- 在老年IBD患者的风险分层和预后中, Sarcopenia评估是一个有价值的工具.
相关概念视频
Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Inflammatory Bowel Disease V: Surgical Management
Here are some common surgical interventions for IBD:
Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease IV: Pharmacological Management
Pharmacologic...
Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...

